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Fusobacterium May Help Colorectal Cancer Grow and Spread
Posted: December 29, 2017Fusobacterium, found in the stomach and intestines, may help fuel the growth of colorectal cancer and metastases. In a mouse model of colorectal cancer, using antibiotics to kill these bacteria slowed tumor growth.
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Low-Tech Outreach Methods Improve Colorectal Cancer Screening
Posted: September 26, 2017Proactive, low-tech outreach approaches can help increase the number of people who get screened for colorectal cancer with a colonoscopy or home stool test and complete the appropriate follow-up.
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FDA Approves Nivolumab for Some Metastatic Colorectal Cancers
Posted: August 17, 2017FDA has granted accelerated approval to the immunotherapy drug nivolumab (Opdivo®) for patients with metastatic colorectal cancer whose tumors have alterations that affect DNA repair.
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Less Chemotherapy May Be Best Choice for Some Patients with Colon Cancer, Study Shows
Posted: June 7, 2017A shorter course of chemotherapy following surgery may be preferred to longer treatment for some patients with colon cancer, results of an international collaborative study suggest.
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Posted: March 23, 2017
Drs. Philip Rosenberg and William Anderson of NCI discuss a recent study on which they were coauthors that reported an increase in colorectal cancer incidence among adults under age 50 in the United States.
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Cellular Immunotherapy Targets a Common Human Cancer Mutation
Posted: December 7, 2016In a study of an immune therapy for colorectal cancer that involved a single patient, researchers identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene.
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Colorectal Cancer Survival Linked to Primary Tumor Location
Posted: May 27, 2016A blog post on a study showing that in patients with metastatic colorectal cancer, the location in the colon where the tumor originated appears to strongly influence how long patients live.
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Survival Disparities Identified in Young African Americans with Colorectal Cancer
Posted: May 25, 2016African Americans younger than age 50 had significantly worse 5-year survival rates at every stage of disease compared with young white and Hispanic patients, a new study shows.
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Drug Combination Shrinks Duodenal Polyps in People with Familial Adenomatous Polyposis
Posted: April 7, 2016In a small clinical trial of people with an inherited condition that greatly increases gastrointestinal cancer risk, a two-drug combination shrank precancerous lesions in the duodenum.
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Mouse Study Points to Mechanism Linking Obesity and Colorectal Cancer Risk
Posted: February 8, 2016A missing hormone in obese mice may help explain a longstanding association between obesity and an increased risk of colorectal cancer in humans.
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FDA Approves Combination Drug for Patients with Advanced Colorectal Cancer
Posted: October 14, 2015The FDA has approved a single drug that combines trifluridine and tipiracil to treat patients with metastatic colorectal cancer whose disease progressed after standard treatment.
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TAS-102 Improves Overall Survival in Patients with Metastatic Colorectal Cancer
Posted: June 12, 2015In an international randomized phase III trial, the investigational drug TAS-102 extended the lives of patients with metastatic colorectal cancer whose disease had progressed following standard therapies.
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Bacterial Biofilms Provide Clues into Colorectal Cancer Risk
Posted: January 16, 2015A new study suggests that dense bacterial communities called biofilms may promote the development of some colorectal cancers.
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Analyzing the Gut Microbiome to Help Detect Colorectal Cancer
Posted: January 13, 2015New research suggests that identifying specific changes in the gut microbiome could potentially help screen patients for colorectal cancer.
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Posted: July 21, 2014
Investigators who analyzed 95 human colorectal tumor samples have determined how gene alterations identified in previous analyses of the same samples are expressed at the protein level. The integration of proteomic and genomic data, or proteogenomics, provides a more comprehensive view of the biological features that drive cancer than genomic analysis alone.
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Posted: July 18, 2012
The pattern of genomic alterations in colon and rectal tissues is the same regardless of anatomic location or origin within the colon or the rectum, leading researchers to conclude that these two cancer types can be grouped as one, according to The Cancer Genome Atlas (TCGA) project’s large-scale study of colon and rectal cancer tissue specimens.
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Sigmoidoscopy Proves to Be Effective Screening Tool for Colorectal Cancer
Posted: June 7, 2012In a large randomized trial involving healthy men and women aged 55 to 74, sigmoidoscopy substantially reduced the incidence of and mortality from colorectal cancer.
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Colonoscopy Reduces Risk of Death from Colorectal Cancer in High-Risk Patients
Posted: March 19, 2012Long-term results from the National Polyp Study confirm that removing precancerous adenomas not only reduces the risk of colorectal cancer but also reduces the number of deaths from the disease by more than half. The findings appeared February 23, 2012, in the New England Journal of Medicine.
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Study Shows Aspirin Reduces Colorectal Cancer in Those at High Risk
Posted: December 2, 2011Findings from the first large clinical trial of its kind indicate that taking high doses of aspirin daily for at least 2 years substantially reduces the risk of colorectal cancer among people at increased risk of the disease.
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Posted: August 30, 2011
In a randomized phase III trial, the addition of the targeted therapy cetuximab to oxaliplatin and fluoropyrimidine chemotherapy did not prolong survival or time to disease progression of patients with advanced colorectal cancer. The results were published on June 5, 2011 in The Lancet.
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When Combined with Chemotherapy, Bevacizumab Is Associated with Increased Risk of Death
Posted: March 30, 2011Cancer patients who receive the targeted therapy bevacizumab (Avastin) in combination with chemotherapy are at increased risk of serious side effects that may lead to death, according to a meta-analysis of 16 clinical trials that was published February 2, 2011, in JAMA.